Panakes are a Gnomish plant capable of curing anything via their blossoms and petals. Panake trees are created when a Gnome sacrifices themselves to create one by turning themselves into a panakes tree. Calla, who is a gnome, at the end of Neverseen, slowed herself down to transform herself into a panakes tree to save the Gnomes from the Ogre-created plague. Her panakes tree now stands on a hill at Havenfield.
- The panakes may be based on the alchemical idea of a Panacea, a medicine capable of curing anything.
- It shares this aspect with Alkahest, another aspect of alchemy.
- They have pretty colored blossoms that can change color.
- Sophie has a panakes perfume given to her by Dex.
- The Panakes tree is in the background of one of Keefe's paintings.
- Keefe once painted Sophie a bead with a panakes blossom on it.